Genipin cross-linked carbon dots for antimicrobial, bioimaging and bacterial discrimination
Chu, XH (Chu, Xiaohong)[ 1,2 ] ; Wu, F (Wu, Fan)[ 1,2 ] ; Sun, BH (Sun, Baohong)[ 1,2 ] ; Zhang, M (Zhang, Ming)[ 1,4 ] ; Song, SJ (Song, Saijie)[ 1,2 ] ; Zhang, P (Zhang, Pan)[ 1,2 ] ; Wang, YL (Wang, Yuli)[ 1,2 ] ; Zhang, QC (Zhang, Qicheng)[ 1,2 ] ; Zhou, NL (Zhou, Ninglin)[ 1,2,3 ]*（周宁琳）; Shen, J (Shen, Jian)[ 1,2 ]*（沈健）
[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biol Funct Mat, Nanjing 210023, Peoples R China
[ 2 ] Jiangsu Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Peoples R China
[ 3 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Nanjing 211505, Peoples R China
[ 4 ] Tech Univ Denmark, Dept Hlth Technol, Lyngby 2800, Denmark
COLLOIDS AND SURFACES B-BIOINTERFACES，202006,190,110930
Multifunctional carbon dots (CDs) present enormous potential in numerous applications and have attracted widespread attention for various applications in the biomedical field. Bacterial infection is a common health issue; the development of antibacterial materials with low toxicity and good biocompatibility is becoming more important. In this work, we synthesized a new type of nitrogen co-doped carbon dots-genipin covalent conjugate (N-CDs-GP) via hydrothermal methods. The microstructure and chemical composition of the N-CDs-GP were characterized. The biocompatibility, stability, antibacterial activity, and fluorescence performance of the N-CDsGP were assessed. The results revealed that N-CDs-GP possessed high biocompatibility, high light stability, and broad antibacterial activity. Additionally, selective Gram-positive bacterial imaging by N-CDs-GP provided a more rapid method of bacterial detection. The N-CDs-GP have the potential to be applied as bioimaging and antibacterial agents and for bacterial discrimination.